Restraint stress differentially affects anti-viral cellular and humoral immune responses in mice.
Identifieur interne : 003481 ( Main/Exploration ); précédent : 003480; suivant : 003482Restraint stress differentially affects anti-viral cellular and humoral immune responses in mice.
Auteurs : J F Sheridan ; N G Feng ; R H Bonneau ; C M Allen ; B S Huneycutt ; R. GlaserSource :
- Journal of neuroimmunology [ 0165-5728 ] ; 1991.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (biosynthèse), Contention physique, Corticostérone (sang), Immunoglobuline G (biosynthèse), Infections à Orthomyxoviridae (anatomopathologie), Infections à Orthomyxoviridae (immunologie), Interleukine-2 (biosynthèse), Lymphocytes T auxiliaires (immunologie), Mâle, Souris, Souris de lignée C57BL, Stress physiologique (immunologie).
- MESH :
- anatomopathologie : Infections à Orthomyxoviridae.
- biosynthèse : Anticorps antiviraux, Immunoglobuline G, Interleukine-2.
- immunologie : Infections à Orthomyxoviridae, Lymphocytes T auxiliaires, Stress physiologique.
- sang : Corticostérone.
- Animaux, Contention physique, Mâle, Souris, Souris de lignée C57BL.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (biosynthesis), Corticosterone (blood), Immunoglobulin G (biosynthesis), Interleukin-2 (biosynthesis), Male, Mice, Mice, Inbred C57BL, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (pathology), Restraint, Physical, Stress, Physiological (immunology), T-Lymphocytes, Helper-Inducer (immunology).
- MESH :
- chemical , biosynthesis : Antibodies, Viral, Immunoglobulin G, Interleukin-2.
- chemical , blood : Corticosterone.
- immunology : Orthomyxoviridae Infections, Stress, Physiological, T-Lymphocytes, Helper-Inducer.
- pathology : Orthomyxoviridae Infections.
- Animals, Male, Mice, Mice, Inbred C57BL, Restraint, Physical.
Abstract
Physical restraint administered to C57BL/6 mice significantly altered the inflammatory response to influenza virus infection and depressed anti-viral cellular immunity. Restraint-stressed animals showed a pattern of reduced mononuclear cell infiltration and lung consolidation which coincided with elevated plasma corticosterone levels. Furthermore, cellular immunity to virus was significantly depressed; interleukin-2 secretion was reduced by 96% and 59% in the mediastinal lymph nodes and spleens, respectively, as compared to a non-restrained group. However, the magnitude of the humoral immune response to influenza virus was unaffected by restraint stress. Anti-viral IgG antibody levels in restrained/infected mice did not differ when compared to a non-restrained/infected control group 14 days post-infection.
DOI: 10.1016/0165-5728(91)90046-a
PubMed: 1847396
Affiliations:
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Le document en format XML
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Restraint-stressed animals showed a pattern of reduced mononuclear cell infiltration and lung consolidation which coincided with elevated plasma corticosterone levels. Furthermore, cellular immunity to virus was significantly depressed; interleukin-2 secretion was reduced by 96% and 59% in the mediastinal lymph nodes and spleens, respectively, as compared to a non-restrained group. However, the magnitude of the humoral immune response to influenza virus was unaffected by restraint stress. Anti-viral IgG antibody levels in restrained/infected mice did not differ when compared to a non-restrained/infected control group 14 days post-infection.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Allen, C M" sort="Allen, C M" uniqKey="Allen C" first="C M" last="Allen">C M Allen</name><name sortKey="Bonneau, R H" sort="Bonneau, R H" uniqKey="Bonneau R" first="R H" last="Bonneau">R H Bonneau</name><name sortKey="Feng, N G" sort="Feng, N G" uniqKey="Feng N" first="N G" last="Feng">N G Feng</name><name sortKey="Glaser, R" sort="Glaser, R" uniqKey="Glaser R" first="R" last="Glaser">R. Glaser</name><name sortKey="Huneycutt, B S" sort="Huneycutt, B S" uniqKey="Huneycutt B" first="B S" last="Huneycutt">B S Huneycutt</name><name sortKey="Sheridan, J F" sort="Sheridan, J F" uniqKey="Sheridan J" first="J F" last="Sheridan">J F Sheridan</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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